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Structured Review

ProSense Inc prosense® 680 molecular imaging
Prosense® 680 Molecular Imaging, supplied by ProSense Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/prosense-680/prosense++680+molecular+imaging/us12264156-2824-7-7
Average 90 stars, based on 1 article reviews
prosense® 680 molecular imaging - by Bioz Stars, 2026-09
90/100 stars

Images

Related Articles

Western Blot:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Expressing:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Incubation:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Fluorescence:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Tomography:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Imaging:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Activation Assay:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Ligation:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Immunofluorescence:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Staining:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Activity Assay:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.

Confocal Microscopy:

Article Title: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury
Article Snippet: Fluorescence molecular tomography (FMT) imaging using ProSense-680 demonstrated increased protease activities around the TTC (2,3,5-triphenyl-2H-tetrazolium chloride)-negative infarcted area, showing enhanced inflammatory milieu in the penumbra.


Article Title: Mapping Molecular Agents Distributions in Whole Mice Hearts Using Born-Normalized Optical Projection Tomography
Article Snippet: In order to characterize the volumetric distribution of the two molecular probes (Prosense-680, Clio-750) and to determine the strength of their colocalization we implemented the Cross Correlation Function (CCF) ( ).

Article Title: Detection of protease activity in cells and animals.
Article Snippet: 100-250 words) Proteases are involved in a wide variety of biologically and medically important events.. They are entangled in a complex network of processes that regulate their activity, which makes their study intriguing, but challenging.. For comprehensive understanding of protease biology and effective drug discovery, it is therefore essential to study proteases in models that are close to their complex native environments such as live cells or whole organisms.

Article Title: Recent advances in nanomedicines for imaging and therapy of myocardial ischemia-reperfusion injury.
Article Snippet: Myocardial ischemia-reperfusion injury (IRI) is becoming a typical cardiovascular disease with increasing worldwide incidence.. It is usually induced by the restoration of normal blood flow to the ischemic myocardium after a period of recanalization and directly leads to myocardial damage.. Notably, the pathological mechanism of myocardial IRI is closely related to inflammation, oxidative stress, Ca2+ overload, and the opening of mitochondrial permeability transition pore channels.

Article Title: Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models.
Article Snippet: NS, not significant. (D, E) Coronal FMT image acquired 24 h after the injection of Prosense-680 and MMPsense-750.

Article Title: Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice.
Article Snippet: In the liver, lung, and pancreas, hypoxia caused by ischaemia has been reported to A B D E F C Figure 4 Effect of TAK-242-NP on inflammation and circulating HMGB1. (A) FMT images visualizing protease activity by ProSense-680 in mice 48 h after IR injury.



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Image Search Results


Table of Materials

Journal: Journal of visualized experiments : JoVE

Article Title: Non-Invasive Compression-Induced ACL Injury and In Vivo Imaging of Protease Activity in Mice

doi: 10.3791/65249

Figure Lengend Snippet: Table of Materials

Article Snippet: Name of Material/ Equipment Company Catalog Number Comments/Description Materials testing systems TA Instruments Electroforce 3200 or equivalent Uniaxial load cell TA Instruments 20 N capacity Fixtures Custom-made knee fixture, ankle fixture, and platform Air Anesthetia System Isoflurane vaporizor with induction chamber and nose cone Buprenorphine Analgesic post-injury IVIS Spectrum Perkin Elmer 124262 Can also use comparable optical imaging system ProSense680 Perkin Elmer NEV10003 Can also use other probes such as OsteoSense, MMPSense, Cat K, AngioSense, etc.

Techniques: Optical Imaging, Cream, Saline, Sterility

Table of Materials

Journal: Journal of visualized experiments : JoVE

Article Title: Non-Invasive Compression-Induced ACL Injury and In Vivo Imaging of Protease Activity in Mice

doi: 10.3791/65249

Figure Lengend Snippet: Table of Materials

Article Snippet: ProSense680 , Perkin Elmer , NEV10003 , Can also use other probes such as OsteoSense, MMPSense, Cat K, AngioSense, etc..

Techniques: Optical Imaging, Cream, Saline, Sterility

Table of Materials

Journal: Journal of visualized experiments : JoVE

Article Title: Non-Invasive Compression-Induced ACL Injury and In Vivo Imaging of Protease Activity in Mice

doi: 10.3791/65249

Figure Lengend Snippet: Table of Materials

Article Snippet: ProSense680 , Perkin Elmer , NEV10003 , Can also use other probes such as OsteoSense, MMPSense, Cat K, AngioSense, etc..

Techniques: Optical Imaging, Cream, Saline, Sterility